Registration Dossier
Registration Dossier
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EC number: 200-539-3 | CAS number: 62-53-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- The test substance was applied to the intact skin (2.5 x 2.5 cm2) on the back of 2 of white Vienna rabbits for 1 min, 5 min, 15 min and 20 h under occlusive conditions. Test substance was removed and skin reactions were recorded on day 1, 2, 5 and 6 similiar to Draize score of the OECD test guideline 404.
- GLP compliance:
- no
Test material
- Reference substance name:
- Aniline
- EC Number:
- 200-539-3
- EC Name:
- Aniline
- Cas Number:
- 62-53-3
- Molecular formula:
- C6H7N
- IUPAC Name:
- aniline
- Details on test material:
- - Name of test material (as cited in study report): aniline
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): undiluted solution (ca. 1 mL) - Duration of treatment / exposure:
- 1, 5 and 15 min, 20 h
- Observation period:
- 24 h and up to 8 days
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 1
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 1
- Reversibility:
- fully reversible within: 2 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48 h
- Score:
- 1
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h - 144 h
- Score:
- 0
Applicant's summary and conclusion
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