Aniline

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: EPA guideline of 1982

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Aniline

EC Number:

200-539-3

EC Name:

Aniline

Cas Number:

62-53-3

Molecular formula:

C6H7N

IUPAC Name:

aniline

Details on test material:

- Name of test material (as cited in study report): aniline
- Analytical purity: no data

Test animals

Species:

rat

Strain:

other: Crl:CD

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 8 weeks
- Weight at study initiation: 230-250g

Administration / exposure

Route of administration:

other: inhalaton exposure to vapour/aerosol

Type of inhalation exposure:

head only

Vehicle:

other: humidified and oxygen-enriched houseline air

Analytical verification of test atmosphere concentrations:

yes

Remarks:

every 30 min

Duration of exposure:

4 h

Concentrations:

681, 790, 834 and 896 ppm

No. of animals per sex per dose:

10/dose group

Results and discussion

Effect levels

Dose descriptor:

LC50

Effect level:

839 ppm

Exp. duration:

4 h

Remarks on result:

other: 839 ppm = 3.27 mg/L, head-only exposure to vapour/aerosol

Any other information on results incl. tables

Deaths occurred at concentrations of 790 ppm (2/10 rats died), 834 ppm (5/10 rats died) and 896 ppm (8/10 rats died). Clinical signs at exposure included cyanosis, tremors and prostration up to 48 hours post-exposure, corneal clouding up to 14 days post-exposure, reddish brown nasal discharge and chromodachryorrhea. Clinical signs post exposure were pallor and rales, head and facial hair loss; after 4 hours exposure to 790 ppm mild to severe corneal damage was detected.