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EC number: 200-539-3 | CAS number: 62-53-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
Aniline is a well known and strong methemoglobin inducer. Neurofunctional and neuropathological effects were observed by Okazaki et al. (2001a and 2001b) after single oral treatment of 4-week old rats with high (750 to 1000 mg/kg bw) doses of aniline, which induced cyanosis and, consequently, mortality. Rats of the same age treated with an aniline dose not inducing cyanosis (500 mg/kg bw) did not show any neurofunctional and/or neuropathological effects. Therefore it can be assumed that the neurological effects seen are a consequence of strong oxygen depletion caused by aniline induced methemoglobin formation in developing young rats. This assumption is supported by the observation that all neurofunctional and neuropathological effects appeared only transiently and could be recovered, respectively. Rats treated in a later stage of development (7-10 week old rats) did not show any neurofunctional and/or neuropathological effects, although treated with a clearly cyanosis inducing aniline dose (800 mg/kg bw). Obviously, more mature rats are no longer susceptible to cyanosis induced transiently appearing neurotoxicity.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
no classification required
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