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EC number: 234-190-3 | CAS number: 10588-01-9
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: various
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The EU RAR summarises the results of a number of studies of largely non-standard design and variable reliability. The findings of these studies are, however, consistent with each other.
Data source
Reference
- Reference Type:
- other: EU RAR
- Title:
- European Union Risk Assessment Report: chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate, potassium dichromate
- Author:
- European Chemicals Bureau
- Year:
- 2 005
- Bibliographic source:
- 3rd Priority List; Volume 53
Materials and methods
- Principles of method if other than guideline:
- The EU RAR summarises the findings of a number of studies designed to investigate the effects of potassium dichromate on the fertility of male and/or female mice following administration in drinking water.
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium dichromate
- EC Number:
- 231-906-6
- EC Name:
- Potassium dichromate
- Cas Number:
- 7778-50-9
- Molecular formula:
- Cr2H2O7.2K
- IUPAC Name:
- potassium dichromate
- Details on test material:
- No further details
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Various
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on mating procedure:
- Various
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- Various
- Frequency of treatment:
- Various
- Details on study schedule:
- Various
- No. of animals per sex per dose:
- Various
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 166 mg/kg bw/day (actual dose received)
- Sex:
- male
- Basis for effect level:
- other: First study
- Remarks on result:
- other: Generation not specified (migrated information)
- Dose descriptor:
- LOAEL
- Effect level:
- 333 mg/kg bw/day
- Sex:
- male
- Basis for effect level:
- other: First study; 12 week dose
- Remarks on result:
- other: Generation not specified (migrated information)
- Dose descriptor:
- LOAEL
- Effect level:
- 400 mg/kg bw/day
- Sex:
- female
- Basis for effect level:
- other: First study; 12 weeks
- Remarks on result:
- other: Generation not specified (migrated information)
- Dose descriptor:
- NOAEL
- Effect level:
- 119 mg/kg bw/day
- Sex:
- female
- Basis for effect level:
- other: Second study; maternal toxicity
- Remarks on result:
- other: Generation not specified (migrated information)
- Dose descriptor:
- NOAEL
- Effect level:
- 63 mg/kg bw/day
- Sex:
- female
- Basis for effect level:
- other: Second study; fertility
- Remarks on result:
- other: Generation not specified (migrated information)
- Dose descriptor:
- NOAEL
- Effect level:
- 86 mg/kg bw/day
- Sex:
- female
- Basis for effect level:
- other: Third study; fertility
- Remarks on result:
- other: Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Adverse effects were produced in mice receiving potassium dichromate for 12 weeks in drinking water at 333 mg/kg bw/d (120 mg Cr(VI)/kg bw/d) and 400 mg/kg bw/day (140 mg Cr(VI)/kg bw/d) and above in males and females respectively. An increase in resorptions following treatment of males and a decrease in implantations in treated females were among the findings in this study. In another study, pregestational oral administration of potassium dichromate in drinking water to female mice produced adverse effects on fertility (reduced number of corpora lutea and increased pre-implantation loss) at 500 ppm (119 mg/kg bw/d (40 mg Cr(VI)/kg bw/d)) and above. In a third study, also in the mouse, at 86 mg/kg bw/d (30 mg Cr(VI)/kg bw/d), the highest dose level tested, there were no effects of treatment on fertility parameters.
Applicant's summary and conclusion
- Conclusions:
- The available data show that potassium dichromate, administered in the drinking water, has adverse effects on reproduction in the mouse.
- Executive summary:
The results of studies performed using the administration of potassium dichromate in drinking water show adverse effects on the fertility of male and female mice. Based on the comparable toxicokinetics and toxicodynamics of the water-soluble hexavalent chromium compounds; similar toxicity can be assumed for all of the compounds in this group.
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