Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Route of exposure not relevant

Data source

Reference
Reference Type:
publication
Title:
Cyclosiloxanes produce fatal liver and lung damage
Author:
Lieberman et al.
Year:
1999
Bibliographic source:
Environmental Health Perspectives 107: 161-165

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octamethylcyclotetrasiloxane
EC Number:
209-136-7
EC Name:
Octamethylcyclotetrasiloxane
Cas Number:
556-67-2
Molecular formula:
C8H24O4Si4
IUPAC Name:
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane

Test animals

Species:
mouse
Strain:
CD-1
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: soy oil
Doses:
no data
No. of animals per sex per dose:
No. of animals 5-12

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
other: acute intraperitoneal
Effect level:
6 000 - 7 000 mg/kg bw
Gross pathology:
At extremely high dose levels there were indications of liver and lung pathology as shown by clinical chemistry and histopathology studies.

Applicant's summary and conclusion