Registration Dossier
Registration Dossier
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EC number: 209-136-7 | CAS number: 556-67-2
Endpoint summary
Administrative data
Description of key information
There is one reliable human clinical study (Dow Corning Corporation, 1997d) and some employee health surveillance data, which is of unknown reliability as the original study report was not available for review (Dow Corning Corporation, 1977).
Additional information
In a human clinical study (Dow Corning Corporation, 1997d), the respiratory intake and uptake of D4 were measured in 12 healthy volunteers following exposure to 10 ppm for 1 hour. Mean D4 intake was 137 +/- 25 mg (SD). Plasma measurement of D4 gave a mean peak value of 79 +/- 5 ng/g (SEM) and indicated a rapid nonlinear blood clearance.
In a health evaluation of employees exposed to D4 conducted to determine whether measurable health effects are produced by long-term exposure to typical concentrations of D4 in the workplace (Dow Corning Corporation, 1977), the 8 hour TWA exposure to D4 was found to range from 0.17 to 2.2 ppm with an average of 0.75 ppm. The highest concentration found during the survey was 4.4 ppm. The results indicate that there are no measurable health effects produced by long-term exposures to typical levels of D4 found in the workplace.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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