Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

A 28-day repeated dose oral toxicity study is not required based on the information requirements outlined in the ECHA REACH fact sheet of 15/09/2009 (ref: ECHA-09-FS-05-EN), as a proposal to address the 90-day repeated dose oral toxicity study in rats is included in the dossier.

The test proposal for a 90-day repeated dose toxicity study is part of an integrated test strategy (ITS), which comprises the following steps:

1. Data for all major constituents of lemon oil should be considered as a first step:

- the currently available data (available data on main constituent d-limonene already included in this dossier)

- data which are expected to become available as a result of the REACH registration of the constituents as such, later during the phase-in period

2. When data from constituents are not sufficient, testing with lime oil should be considered.

Justification for classification or non-classification