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EC number: 202-679-0 | CAS number: 98-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- publication
- Title:
- ACUTE TOXICITY AND PRIMARY IRRITATION OF PARA-TERTIARY BUTYLPHENOL
- Author:
- Klonne DR, Myers RC, Nachreiner DJ & Homan ER
- Year:
- 1 988
- Bibliographic source:
- DRUG AND CHEMICAL TOXICOLOGY, 11(1), 43-54 (1988)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- - reliability scoring based on 1981 guideline
- Deviations:
- yes
- Remarks:
- - test concentration was 5.6 mg/L for 4-h exposure test; chamber volume > 20 L for 6-h exposure test; see Additional Information on Material and Methods
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-tert-butylphenol
- EC Number:
- 202-679-0
- EC Name:
- 4-tert-butylphenol
- Cas Number:
- 98-54-4
- Molecular formula:
- C10H14O
- IUPAC Name:
- 4-tert-butylphenol
- Details on test material:
- - Name of test material (as cited in study report): para-tertiary butylphenol, UCAR Butylphenol 4T-Flake (para tert-Butyl Phenol), PTBP.
- Physical state: White flakes.
- Analytical purity: Not reported.
- Lot/batch No.: Charge No. 496500; BRRC Sample No. 48-186.
- Expiration date of the lot/batch: Not reported.
- Stability under test conditions: Not reported.
- Storage condition of test material: Not reported.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Zivic-Miller Laboratories, Inc., Zelienople, PA; Harlan Sprague Dawley, Inc., Indianapolis, IN.
- Age at study initiation: Not reported.
- Weight at study initiation: Between 200 and 300 g.
- Fasting period before study: Not reported.
- Housing: Not reported.
- Diet (e.g. ad libitum): Animals were maintained on appropriate commercial diet, ad libitum.
- Water (e.g. ad libitum): Animals were maintained on municipal water, ad libitum.
- Acclimation period: At least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported.
- Humidity (%): Not reported.
- Air changes (per hr): Not reported.
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- other: Test 1: Vapour (6-hour exposure study); Test 2: dust aerosol (4-hour exposure study)
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Groups of 5 male and five female rats were exposed for 6 hour to a substantially saturated vapor of PTBP under static conditions (Test 1) or for 4 hour to a dynamically generated dust aerosol (Test 2).
Test 1: For the static vapor exposure, 100 g of PTBP was placed in a 120 L Plexiglas® (Rohm & Hass Co.) and stainless steel chamber for approximately 18 hour at ambient temperature prior to introduction of the male or female rats. Oxygen content was maintained at greater than 19% during the exposure.
Test 2: A respirable dust aerosol was produced to simulate industrial preparation of PTBP by melting the flakes in a flask maintained at 110°C. Filtered compressed air then carried the vapors to a 120 L Plexiglas® chamber where the PTBP condensed in air to a fine powder. The dust concentration was determined by standard gravimetric techniques using 47 mm glass fiber filters. The particle size distribution was determined with a TSI Model APS 3300 Aerodynamic Particle Sizer (St. Paul, MN) fitted with an In-Tox Products dilutor (Albuquerque, NM). The mass median aerodynamic diameter (MMAD) and geometric standard deviation were calculated by probit analysis. To assess the vapor concentration of PTBP in the chamber, air samples were pulled through 2 midget impingers containing acetone, after first filtering out all solid particulate material with glass fiber filters. Liquid samples were then analyzed with a gas chromatograph fitted with a flame ionization detector. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Test 2: average aerosol concentration was gravimetrically determined; Test 1: concentration of test substance in air not reported.
- Duration of exposure:
- 6 h
- Remarks on duration:
- For Test 1; 4 h exposure for Test 2
- Concentrations:
- Test 1: 100 g of test substance was placed in 120 L chamber.
Test 2: 5.6 mg/L. - No. of animals per sex per dose:
- 5/sex/group.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days for Tests 1 and 2.
- Frequency of observations and weighing: For Tests 1 and 2, clinical signs of toxicity were observed once daily during post-exposure period. Body weights were measured on Days 0, 7 and 14 for both Tests 1 and 2.
- Necropsy of survivors performed: Yes (for Tests 1 and 2). - Statistics:
- Statistical analysis is not required (Acute toxicity test).
Results and discussion
- Preliminary study:
- Not applicable.
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- other: No LD50 value determined
- Effect level:
- 100 other: g in 120 L chamber
- Exp. duration:
- 6 h
- Remarks on result:
- other: Test 1: 6 hour exposure killed 0 of 10 animals.
- Key result
- Sex:
- male/female
- Dose descriptor:
- other: No LD50 value determined
- Effect level:
- 5.6 mg/L air (nominal)
- Exp. duration:
- 4 h
- Remarks on result:
- other: Test 2: 20% mortality was observed
- Mortality:
- Test 1: None of the 10 animals died during the 6 hour exposure.
Test 2: Within 1 to 2 days following exposure, 1 of 5 male rats and 1 of 5 female rats died. - Clinical signs:
- other: Test 1: There were no effects in rats from exposure to a statically generated substantially saturated vapor for 6 hours on clinical signs. Test 2: Clinical signs observed on the day of exposure and up to 7 days post-exposure included signs of mucosal ir
- Body weight:
- Test 1: There were no effects in rats from exposure to a statically generated substantially saturated vapor for 6 hours on body weight.
Test 2: A loss of mean body weight was observed for both sexes on post-exposure Day 7, but body weight gains were exhibited on Day 14. - Gross pathology:
- Test 1: There were no effects in rats from exposure to a statically generated substantially saturated vapor for 6 hours on necropsy observations.
Test 2: Dark red or purple discoloration of the lungs and/or kidneys were observed in the two rats that died but no macroscopic lesions were observed in survivors. - Other findings:
- Test 2: The 4 hour dynamic exposure was conducted at a mean ± standard deviation concentration of 5.6 ± 0.8 mg/L of PTBP dust aerosol, with an additional vapor component of 0.03 mg/L. The MMAD for the dust was 3.6 microns with an geometric standard deviation of 2.0.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)
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