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Registration Dossier
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EC number: 202-679-0 | CAS number: 98-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Dose-dependent shifts in the sulfation and glucoronidation of phenolic compounds in the rat in vivo and in isolated hepatocytes
- Author:
- Koster H, Halsema I, Scholtens E, Knippers M, Mulder GJ
- Year:
- 1 981
- Bibliographic source:
- Biochem Pharmacol; 30(18):2569-75
- Reference Type:
- publication
- Title:
- Ecotoxicological profile analysis
- Author:
- Freitag D, Geyer H, Kraus A, Viswanathan R, Kotzias D, Attar A, Klein W, Korte F.
- Year:
- 1 982
- Bibliographic source:
- Ecotoxicol Environmental Safety; 6:60-81
Materials and methods
Test material
- Reference substance name:
- p-tert.-Butylphenol
- IUPAC Name:
- p-tert.-Butylphenol
- Details on test material:
- - Name of test material (as cited in study report): p-tert.-Butylphenol
- Substance type: pure active substance
- Physical state: solid
- Stability under test conditions: no data
- Storage condition of test material: under nitrogen in the dark
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Based on the physicochemical properties of ptBP alone [i.e., low molecular weight (150.22 g/mol), low Kow value (3.29), and high water solubility (610 mg/L)], the absorption of ptBP from various routes of exposure is expected to be 100%. Consistent with this assumption, ptBP has been demonstrated to be absorbed following oral administration as determined in rats. Signs of toxicity observed in experimental animals following oral exposure to ptBP also are indicative of systemic absorption. An oral absorption percentage of 100% is applied to ptBP based on in vivo animal data showing elimination of a substantial amount of an orally administered dose (147 µg/kg body weight/day for 3 days) via urine and feces at levels of 72.9% and 26.7%, respectively; whether the material detected in fecal samples occurred as unabsorbed ptBP or as ptBP metabolites eliminated via bile was not determined. Although, no systemic toxicity was observed in experimental animals upon acute dermal exposure, the results of human biomonitoring studies have demonstrated that ptBP is systemically absorbed intact following dermal, as well as inhalational exposures. Data specifically addressing the percentage of absorption from inhalational and dermal exposure are lacking, and therefore, a default absorption value of 100% is considered for ptBP. Whether ptBP would be expected to cross the placental barrier cannot be deduced from the reproductive toxicity study conducted in rats.
Following oral absorption, a small amount of the compound is distributed to the liver in rats, but not to adipose tissue or lungs. Biomonitoring of urine samples from workers handling ptBP indicate that ptBP is metabolized to hydrolysed sulphate and glucuronide conjugates, which is consistent within vivo animal data, as well as in vitro data. Elimination of ptBP conjugates occurs predominantly via the urine, but also occurs in the feces as demonstrated in rats. As mentioned, whether the material detected in rat fecal samples occurred as unabsorbed ptBP or as ptBP metabolites eliminated via bile was not determined in that particular study; however, additional data show that ptBP metabolites are eliminated in the bile to some extent in rats. Taking into consideration the high water solubility of the compound and the extent of phase II metabolism, ptBP is not expected to bioaccumulate. Instead, the retention of ptBP in rats has been shown to be negligible at 0.1% 7 days after an oral dose of ptBP (147 µg/kg body weight/day for 3 days). Moreover, urinary ptBP levels detected following occupational exposure were observed to decrease when workers were away from the workplace, with metabolites eliminated from the urine within 24 hours. The biological half-life of ptBP in urine was calculated to be 4 hours.
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