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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Very concise study, chemical identity of test substance not reported. Diet and environmental conditions not reported. Non GLP study and no Guideline followed, but acceptable basic data.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: Federal Hazardous Substance Act (FHSA)
Deviations:
no
Principles of method if other than guideline:
The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Based on the results an LD50 was established.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Cinnamomum zeylanicum, ext.
EC Number:
283-479-0
EC Name:
Cinnamomum zeylanicum, ext.
Cas Number:
84649-98-9
Molecular formula:
Not Applicable due to UVCB
IUPAC Name:
Cinnamomum zeylanicum, ext.
Constituent 2
Reference substance name:
Cinnamon leaf oil
IUPAC Name:
Cinnamon leaf oil
Details on test material:
- Name of test material (as cited in study report): Cinnamon leaf oil
- Lot/batch No.: confidential

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 hr
Doses:
5000 mg/kg
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Skin Irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.
Executive summary:

The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Skin irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits. No animals died during the test period. The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.