Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 283-479-0 | CAS number: 84649-98-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum zeylanicum, Lauraceae.
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Very concise study, chemical identity of test substance not reported. Diet and environmental conditions not reported. Non GLP study and no Guideline followed, but acceptable basic data.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Federal Hazardous Substance Act (FHSA)
- Deviations:
- no
- Principles of method if other than guideline:
- The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Based on the results an LD50 was established.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Cinnamomum zeylanicum, ext.
- EC Number:
- 283-479-0
- EC Name:
- Cinnamomum zeylanicum, ext.
- Cas Number:
- 84649-98-9
- Molecular formula:
- Not Applicable due to UVCB
- IUPAC Name:
- Cinnamomum zeylanicum, ext.
- Reference substance name:
- Cinnamon leaf oil
- IUPAC Name:
- Cinnamon leaf oil
- Details on test material:
- - Name of test material (as cited in study report): Cinnamon leaf oil
- Lot/batch No.: confidential
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hr
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Skin Irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.
- Executive summary:
The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Skin irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits. No animals died during the test period. The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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