Cinnamomum zeylanicum, ext.

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Very concise study, chemical identity of test substance not reported. Diet and environmental conditions not reported. Non GLP study and no Guideline followed, but acceptable basic data.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: Federal Hazardous Substance Act (FHSA)

Deviations:

no

Principles of method if other than guideline:

The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Based on the results an LD50 was established.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Cinnamomum zeylanicum, ext.

EC Number:

283-479-0

EC Name:

Cinnamomum zeylanicum, ext.

Cas Number:

84649-98-9

Molecular formula:

Not Applicable due to UVCB

IUPAC Name:

Cinnamomum zeylanicum, ext.

Constituent 2

Reference substance name:

Cinnamon leaf oil

IUPAC Name:

Cinnamon leaf oil

Details on test material:

- Name of test material (as cited in study report): Cinnamon leaf oil
- Lot/batch No.: confidential

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Duration of exposure:

24 hr

Doses:

5000 mg/kg

No. of animals per sex per dose:

10

Control animals:

no

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

Skin Irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.

Executive summary:

The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Skin irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits. No animals died during the test period. The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.