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EC number: 283-479-0 | CAS number: 84649-98-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum zeylanicum, Lauraceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Very concise study, chemical identity of test substance not reported. Diet and environmental conditions not reported. Non GLP study and no Guideline followed, but acceptable basic data.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Federal Hazardous Substance Act (FHSA)
- Deviations:
- no
- Principles of method if other than guideline:
- The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Based on the results an LD50 was established.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Cinnamomum zeylanicum, ext.
- EC Number:
- 283-479-0
- EC Name:
- Cinnamomum zeylanicum, ext.
- Cas Number:
- 84649-98-9
- Molecular formula:
- Not Applicable due to UVCB
- IUPAC Name:
- Cinnamomum zeylanicum, ext.
- Reference substance name:
- Cinnamon leaf oil
- IUPAC Name:
- Cinnamon leaf oil
- Details on test material:
- - Name of test material (as cited in study report): Cinnamon leaf oil
- Lot/batch No.: confidential
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hr
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Skin Irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.
- Executive summary:
The acute dermal toxicity of Cinnamon leaf oil in the rabbit was assessed. 10 Rabbits were treated with Cinnamon leaf oil by dermal application of 5000 mg/kg. The animals were observed and mortality and skin irritations were recorded. Skin irritation: moderate redness - 4/10 rabbits; marked redness - 6/10 rabbits ; moderate edema - 6/10 rabbits ; marked edema - 4/10 rabbits. No animals died during the test period. The median lethal dose of Cinnamon leaf oil after dermal application to rabbits is: LD50 (rabbit) > 5000 mg/kg. Based on these results the substance does not have to be classified according to the EU classification criteria outlined in 67/548/EEC and 1272/2008.
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