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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets National standards method with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Principles of method if other than guideline:
Four albino rats were exposed to a saturated atmosphere (nominal concentration: 0.15 mg/l) for 7 hours at room temperature.
GLP compliance:
no
Test type:
fixed concentration procedure

Test material

Constituent 1
Details on test material:
No data

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Concentrations:
saturated atmosphere (nominal concentration: 0.15 mg/l)
No. of animals per sex per dose:
4

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
0.15 mg/L air
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: limited data
Mortality:
0%
Clinical signs:
other: Moderate eye and nasal irritation was observed in all animals during the exposure
Body weight:
No adverse body weight changes

Applicant's summary and conclusion

Conclusions:
The 7 hour LC 50 > 0.15mg/l (a saturated atmosphere).
Executive summary:

The exposure of 4 albino rats to the saturated atmosphere (nominal concentration (0.15 mg/l) for 7 hours at room temperature resulted in 100% survival. Moderate eye and nasal irritation was observed in all animals during the exposure.