Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-650-8 | CAS number: 123-77-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case report
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact Dermatitis from Azodicarbonamide in Earplugs.
- Author:
- Yates VM ; Dixon JE
- Year:
- 1 988
- Bibliographic source:
- Contact Dermatitis, Vol. 19, No. 2, pages 155-156, 1988
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- C,C'-azodi(formamide)
- EC Number:
- 204-650-8
- EC Name:
- C,C'-azodi(formamide)
- Cas Number:
- 123-77-3
- Molecular formula:
- C2H4N4O2
- IUPAC Name:
- diazene-1,2-dicarboxamide
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- A 58-year-old textile worker presented with recurrent bilateral otitis externa.
During the course of his work, he wore yellow foam earplugs (EAR plugs; Cabot Safety Ltd.).
Patch tests to the ICDRG standard series were negative but a positive (++) reaction to his earplug was noted at 48 and 96 h.
3 months later, he was patch tested to the components of the earplugs. These included the blowing agent, azodicarbonamide.
Results and discussion
- Results of examinations:
- Patch tests to azodicarbonamide 1% pet. and 5% pet. were repeated in 10 controls with negative results.
The patient's otitis externa cleared on discarding his earplugs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
