Registration Dossier
Registration Dossier
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EC number: 203-234-3 | CAS number: 104-76-7
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not available. Documentation insufficient for assessment. Treatment period (9 days) insufficient and not in accordance with current test guidelines
Data source
Reference
- Title:
- No information
- Author:
- EPA
- Year:
- 1 988
- Bibliographic source:
- Document No. 86-8870000331, Microfiche No. OTS0516482
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to TSCA and EPA guidelines
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-ethylhexan-1-ol
- EC Number:
- 203-234-3
- EC Name:
- 2-ethylhexan-1-ol
- Cas Number:
- 104-76-7
- Molecular formula:
- C8H18O
- IUPAC Name:
- 2-ethylhexan-1-ol
- Details on test material:
- Purity >99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 9 days
- Frequency of treatment:
- 5 days treatment, 2 days no treatment, 4 days treatment
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.5, 1.0 ml/kg/day (= 0, 417, 834 mg/kg bw/day)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Post-exposure period: none
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There were no treatment-related effects on clinical signs of
toxicity, food consumption, or body weight following
cutaneous exposure to 2-ethylhexanol. Lymphopenia and decreased spleen weight for high dose females and increased
triglycerides for females at both dose levels compared to
controls were observed. No other treatment-related effects
on clinical pathology measurements or organ weights were
observed for males or females at either dose level.
Treatment-related anatomic and histologic lesions observed
following cutaneous exposure to 2-ethylhexanol were
restricted to the site of application and included
exfoliation, acanthosis, hyperkeratosis, eschar formation,
dermatitis and edema.
Applicant's summary and conclusion
- Conclusions:
- Not Assignable. Original reference not yet available. Documentation insufficient for assessment.
Treatment period (9 days) insufficient and not in accordance with current test guidelines.
Reportedly, there were local skin reactions but no systemic toxicity noted following repeated dermal application (9 days).
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