2-ethylhexan-1-ol

Short-term toxicity to aquatic invertebrates

Description of key information

Toxicity to Daphnia magna was moderate (EC50, 48 h: 39 mg/L).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

39 mg/L

Additional information

Valid data on the toxicity of 2-ethylhexanol to crustaceae indicate moderate toxicity:

Endpoint	Organism	Species	Value [mg/L]	Reliability
48 hr EC50	crustacea	Daphnia magna	39	2

The key study on Daphnia magna acute toxicity (48 hours, static design) was performed with the submission substance according to EU method C.2 and compliant to GLP. In the otherwise reliable test analytical verification of test item concentration is lacking (reliability category 2). The EC50 (48 h) was determined as 39 mg/L, EC0 (48 h) and EC100 (48 h) were 28 mg/L and 80 mg/L, respectively.

Further non-reliable studies are available (restricted to 24 hours of exposure, no original study reports) which support the key study:

EC50 (24h, Daphnia magna) 44 mg/L;

EC50 (24h, Brine shrimp) 19 mg/L;

While covering only 24 hours of exposure and being not reliable, these values are very close to the EC50 determined in the reliable key study and thus support the EC50 (48h) of 39 mg/L for aquatic invertebrates, which is used for chemical safety assessment.