Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-589-7 | CAS number: 122-99-6
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental studies on toxicity of ethylene glycol ethers in Japan
- Author:
- Nagano, K. et al.
- Year:
- 1 984
- Bibliographic source:
- Environ Health Perspect 57:75-84
Materials and methods
- Principles of method if other than guideline:
- Evaluation of the toxicity of ethylene glycol alkyl ethers to the testis of mice.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2-phenoxyethanol
- EC Number:
- 204-589-7
- EC Name:
- 2-phenoxyethanol
- Cas Number:
- 122-99-6
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 2-phenoxyethan-1-ol
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Ethylene glycol monophenyl ether
- Analytical purity: no data
- Other: Source: Wako Chemical Co.
Test animals
- Species:
- mouse
- Strain:
- ICL-ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: The authors mention water and olive oil as vehicles, without specifying which vehicle was actually used for the test substance.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 weeks
- Frequency of treatment:
- 5 days per week
- Duration of test:
- 5 weeks
Doses / concentrationsopen allclose all
- Dose / conc.:
- 500 mg/kg bw/day (nominal)
- Dose / conc.:
- 1 000 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/kg bw/day (nominal)
- Sex:
- male
- Basis for effect level:
- organ weights and organ / body weight ratios
Observed effects
Any other information on results incl. tables
Ethylene glycol monomethyl and ethyl ethers and acetates and ethylene glycol dimethyl ether were tested in this study and were found to produce decreased testicular weights and leukocyte counts and dose-related atrophy of the seminiferous tubule epithelium.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
