2-phenoxyethanol

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: Biomonitoring and exposure data

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Biologisches Monitoring zur Expositionserfassung von 2-Phenoxyethanol in der Allgemeinbevölkerung

Author:

Göen, T. et al.

Year:

2001

Bibliographic source:

Verhl. Dt. Ges. Arbeitsmed. Umweltmed., 41. Jahrestagung, Erlangen: 212–216

Materials and methods

Study type:

study with volunteers

Endpoint addressed:

neurotoxicity

Principles of method if other than guideline:

not applicable

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethanol

EC Number:

204-589-7

EC Name:

2-phenoxyethanol

Cas Number:

122-99-6

Molecular formula:

C8H10O2

IUPAC Name:

2-phenoxyethan-1-ol

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-Phenoxyethanol
- Analytical purity: no data

Method

Type of population:

occupational

Subjects:

- Number of subjects exposed: 379 workers

Ethical approval:

not applicable

Route of exposure:

dermal

Reason of exposure:

other: use of skin care products at work and at home

Exposure assessment:

not specified

Examinations:

Detection of 2-phenoxyethanol in urine

Results and discussion

Clinical signs:

not examined

Results of examinations:

- Urine analysis: In 89 % of the samples 2-phenoxyethanol was detected (>= 0.1 mg/l, Cmax= 151 mg/l). In the rotation printing area significantly elevated 2-phenoxyethanol levels were detected compared to the delivery area.