Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 273-925-2 | CAS number: 69227-11-8 A scum formed on the surface of molten copper.
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
There is no explicit requirement to generate toxicokinetic data under REACH. However, Annex I, Section 1.0.2 of REACH states that “the human health hazard assessment shall consider the toxicokinetic profile (i.e. absorption, metabolism, distribution and elimination) of the substance”. Furthermore, REACH in Annex VIII, Section 8.8.1 mentions that one should perform “assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information”.
Reasons to consider relevant available information on toxicokinetic may be to interpret other human health data, to assist in developing a testing strategy and study design and to help optimising test designs. However, a UVCB substance consists of a wide range of constituents that were already tested and assessed in separate risk assessments. As such Toxicokinetic data of the individual constituent were fully discussed in the associated registration dossiers. Toxicokinetic data of the individual constituents are not presented here. Information considered relevant is reported in IUCLID Section 7 “Toxicological information”.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
