Registration Dossier
Registration Dossier
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EC number: 200-579-1 | CAS number: 64-18-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium formate
- EC Number:
- 205-488-0
- EC Name:
- Sodium formate
- Cas Number:
- 141-53-7
- Molecular formula:
- CHO2Na
- IUPAC Name:
- sodium formate
- Details on test material:
- TS-Freetext:
Sodium formate, purity 100%.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
Mortality: no mortality occurred.
Systemic effects: none seen during the observation period.
Local effects: none seen during the observation period.
Body weights: the mean body weight of males increased throughout the observation period. Females did not adequately gain body weight during the first week after treatment, but during the second week.
Mean body weights (g):
===================================================
day 0 day 7 day 14
---------------------------------------------------
Males 269 285 311
Females 222 225 236
===================================================
Pathology: no macroscopic abnormalities noted at terminal examination.
Applicant's summary and conclusion
- Conclusions:
- CL-Freetext:
Under the conditions of this study the acute dermal median lethal dose (LD50) of
Natriumformiat (Sodium formate) after dermal application was found to be greater than
2000 mg/kg body weight in male and female rats.
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