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Sediment toxicity

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Reference
Endpoint:
sediment toxicity: long-term
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
other: ISO 10872
GLP compliance:
yes
Specific details on test material used for the study:
Test item: Silicic acid Aluminium Magnesium Sodium Salt
CAS No.: 12040-43-6
Test organisms (species):
Caenorhabditis elegans
Details on test organisms:
Caenorhabditis elegans, strain N2; J1 at test begin (mean initial body length: 262 (± 15 SD) µm)
Study type:
laboratory study
Type of sediment:
artificial sediment
Remarks:
Formulated sediment (according to ISO 10872) spiked with dispersions of the test item in water
Limit test:
no
Duration:
96 h
Test temperature:
19.8 – 20.3 °C
Nominal and measured concentrations:
Test concentrations:
nominal: 50, 200, 400, 800, 1600, 3200, 5000 mg/kg dry weight
Reference substance (positive control):
yes
Remarks:
Benzylcetyldimethylammonium chloride monohydrate (BAC-C16; 15 mg/l in aqueous medium)
Key result
Duration:
96 h
Dose descriptor:
LOEC
Effect conc.:
> 5 000 mg/kg sediment dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Key result
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
>= 5 000 mg/kg sediment dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Validity criteria fulfilled:
yes
Conclusions:
No inhibitory toxic effects occurred on growth and reproduction of C. elegans up to nominal concentrations of 5000 mg/kg sediment dry weight (dw). Thus a NOEC of 5000 mg/kg sediment dw based on nominal concentrations was determined. Between 200 and 3200 mg/kg sediment dw, significant stimulatory effects on reproduction occurred.

Description of key information

No inhibitory toxic effects occurred on growth and reproduction of C. elegans up to nominal concentrations of 5000 mg/kg sediment dry weight (dw) with the read-across substance Silicic acid, aluminum magnesium sodium salt (CAS 12040-43-6, SMAS). Thus, a NOEC of 5000 mg/kg sediment dw based on nominal concentrations was determined. Between 200 and 3200 mg/kg sediment dw, significant stimulatory effects on reproduction occurred.

Key value for chemical safety assessment

Additional information

Since no studies investigating the sediment toxicity of Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) are available, a read-across to the structurally related Silicic acid, aluminum magnesium sodium salt (CAS 12040-43-6, SMAS) was conducted. This read-across is justified within the analogue justification in IUCLID Section 13.