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Diss Factsheets
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EC number: 241-034-8 | CAS number: 16961-83-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published case report involving sodium hexafluorosilicate
Data source
Reference
- Reference Type:
- publication
- Title:
- CASE HISTORY OF ACUTE POISONING BY SODIUM FLUOROSILICATE
- Author:
- DADEJ N, KOSIMIDER K, MACHOY Z & SAMUJILO D
- Year:
- 1 987
- Bibliographic source:
- FLUORIDE; 20 (1). 1987. 11-13.
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Published case report involving sodium hexafluorosilicate
- GLP compliance:
- no
- Remarks:
- : not relevant
Test material
- Reference substance name:
- sodium hexafluorosilicate
- IUPAC Name:
- sodium hexafluorosilicate
- Details on test material:
- Sodium hexafluorosilicate
Constituent 1
Method
- Subjects:
- One female (32 years old); intentional (suicidal) exposure
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
Results and discussion
- Clinical signs:
- Immediate vomiting, then facial numbness, diarrhoea, diaphoresis, muscle spasms, weakness, abdominal pain, dyspnoea, shallow breathing, and cramps of the palms, feet, and legs. Tachycardia and tachypnea were observed. After 12 hours, generalized weakness and enlargement of the liver continued.
Any other information on results incl. tables
Treatment with calcium compounds (calcium carbonate initially; calcium lactogluconate for ten days after life-threatening symptoms had diminished) resulted in recovery within 21 days. Fluoride levels in serum and urine were 5.130 and 235.60 mg/dm3, respectively, on day 2 of hospitalization. Treatment with calcium compounds (calcium carbonate and calcium lactogluconate) immediately returned levels to normal. The following day, the levels dropped to 0.399 and 15.39 mg/dm3, respectively; by day 20, the levels were 0.067 and 0.87 mg/dm3, respectively.
Applicant's summary and conclusion
- Conclusions:
- The signs and symptoms of toxicity in this poisoning case are consistent with fluoride poisoning.
- Executive summary:
A case report of a suicide attempt is reported.
A female chemical plant worker (32 years old) who ingested three teaspoons of sodium hexafluorosilicate immediately began vomiting, and then experienced facial numbness, diarrhea, diaphoresis, muscle spasms, weakness, abdominal pain, dyspnea, shallow breathing, and cramps of the palms, feet, and legs. Tachycardia and tachypnea were observed. After 12 hours, generalized weakness and enlargement of the liver continued. Treatment with calcium compounds (calcium carbonate initially; calcium lactogluconate for ten days after life-threatening symptoms had diminished) resulted in recovery within 21 days. Fluoride levels in serum and urine were markedly elevated; no effect were apparent on the level of fluoride in nails. The signs and symptoms of toxicity in this poisoning case are consistent with fluoride poisoning.
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