Hexafluorosilicic acid

Biological effects monitoring

Administrative data

Endpoint:

biological effects monitoring

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: mesocosm study

Data source

Reference

Reference Type:

review article or handbook

Title:

Integrated criteria document fluorides

Author:

Janssen PJCM, Janus JA, Knaap AGAC

Year:

1989

Bibliographic source:

National Institute of Public Health and Environmental Protection Bilthoven, The Netherlands, Appendix to report no. 758474010

Materials and methods

Principles of method if other than guideline:

In an outdoor estuarine model ecosystem with mud, eelgrass, juvenile pawns and shrimp, the mud crap and fish exposure to an average concentrationof 52 mg F-/L resulted in increased mortality of the crad an the fish and appeared to affect the reproduction of the shrimp. No other concentrations were used in that test (Hemens and Warwick 1972). In two other experiments lower fluoride concentrations were tested in this model ecosystem, using the same organisms except the shrimp. In the first experiment no adverse effect on survival was found at 5.9 mg F-/L after 10 weeks of exposure with exception of a significantly reduced growth rate of the smallest of the two size classes of fish used. In the second experiment no adverse effects were on survival and growth were found at 5.7 mg F-/L after 16 weeks of exposure with exception of some mortality (16%, statistically not significant) among te exposed fish. In both tests no other concentrations were used.

GLP compliance:

no

Test material

Test material information

1

Reference substance name:

Sodium fluoride

EC Number:

231-667-8

EC Name:

Sodium fluoride

Cas Number:

7681-49-4

Molecular formula:

FNa

IUPAC Name:

sodium fluoride

Specific details on test material used for the study:

The fluoride concentration was reported. Since no reference substance exists for fluoride ions, the reference substance was set to sodium fluoride.

Results and discussion

Any other information on results incl. tables

In an outdoor estuarine model ecosystem with mud, eelgrass, juvenile pawns and shrimp, the mud crab and fish exposure to an average concentration of 52 mg F-/L resulted in increased mortality of the crab an the fish and appeared to affect the reproduction of the shrimp. No other concentrations were used in that test (Hemens and Warwick 1972). In two other experiments lower fluoride concentrations were tested in this model ecosystem, using the same organisms except the shrimp. In the first experiment no adverse effect on survival was found at 5.9 mg F-/L after 10 weeks of exposure with exception of a significantly reduced growth rate of the smallest of the two size classes of fish used. In the second experiment no adverse effects were on survival and growth were found at 5.7 mg F-/L after 16 weeks of exposure with exception of some mortality (16%, statistically not significant) among the exposed fish. In both tests no other concentrations were used.

Applicant's summary and conclusion

Executive summary:

In an outdoor estuarine model ecosystem with mud, eelgrass, juvenile pawns and shrimp, the mud crap and fish exposure to an average concentrationof 52 mg F-/L resulted in increased mortality of the crad an the fish and appeared to affect the reproduction of the shrimp. No other concentrations were used in that test (Hemens and Warwick 1972). In two other experiments lower fluoride concentrations were tested in this model ecosystem, using the same organisms except the shrimp. In the first experiment no adverse effect on survival was found at 5.9 mg F-/L after 10 weeks of exposure with exception of a significantly reduced growth rate of the smallest of the two size classes of fish used. In the second experiment no adverse effects were on survival and growth were found at 5.7 mg F-/L after 16 weeks of exposure with exception of some mortality (16%, statistically not significant) among the exposed fish. In both tests no other concentrations were used.

The NOEC is considered to be 5.7 mg F-/L.