Registration Dossier
Registration Dossier
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EC number: 226-076-7 | CAS number: 5263-02-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No data on materials and methods; the authors reference to a publication which is written in Russian language.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and character of the effect of some zinc compounds
- Author:
- Shabalina LP and Spiridonova VS
- Year:
- 1 988
- Bibliographic source:
- Journal of hygiene, epidemiology, microbiology and immunology. Volume 32, issue 4, pages 397-405
Materials and methods
- Principles of method if other than guideline:
- Method is described in: "Problems of industrial toxicology, Editorial section of the managing department of the Secretariat of CMEA." Title: "Methodological instructions for the organization of studies for the substantiation of standards of harmful substances in the air of the working zone" (in Russian)
- GLP compliance:
- not specified
- Test type:
- other: unkown
Test material
- Reference substance name:
- 12539-71-8
- Cas Number:
- 12539-71-8
- IUPAC Name:
- 12539-71-8
- Details on test material:
- - Name of test material (as cited in study report): zinc carbonate basic monohydrate (2 ZnCO3 . 3Zn(OH)2 . H2O)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no further data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: Mortality, body mass, summation-threshold index (STI) and rectal temperature
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Remarks on result:
- other: basic zinc carbonate monohydrate (tested in this study)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 9 687 mg/kg bw
- Remarks on result:
- other: calculated for the anhydrous zinc carbonate, basic (see below)
Any other information on results incl. tables
Calculation:
According to the study report, the molecular weight of the substance tested (basic zinc carbonate monohydrate) is 576 g / mole. One molecule of water has a molecular weight of about 18 g / mole. Thus the anhydrous basic zinc carbonate has a molecular weight of 558 g / mole. Because 3,125 % tested substance of the high dose (10000 mg/kg) is actually water, the amount of anhydrous basic zinc carbonate test is 9687 mg/kg bw.
Applicant's summary and conclusion
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