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Diss Factsheets
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EC number: 201-250-5 | CAS number: 80-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short -term toxicity
Short-term ecotoxicity data for freshwater at three trophic levels are available. The acute toxicity test showed that Daphnia is the most sensitive species with a EC50 of 55 mg/L.
The LC50 (96 h) to fish was indeed determined to be above the limit dose of 100 mg/L.
In a growth inibition test conducted with the green algaeDesmodesmus s.an EC50 (72 h) of 106 mg/L and a NOEC of 10.2 mg/L were derived.
Long-term toxicity
A NOEC (21 d) of 2.7 mg/L was derived in a reproduction test conducted withDaphnia magna.
A range finding early life stage test was conducted to assess the effects of DHDPSon the most critical and sensitive life-stages of a freshwater fishzebrafish(Danio rerio)and to target test concentrations for a definitive extended one generation reproduction test.
A NOEC for survival of ≥ 10 mg/L was derived. For growth impairment the NOEC was ≥ 10 mg/L
A zebrafish extended one generation reproduction test (ZEOGRT) was conducted to assess the potential effects of DHDPS on population-relevant apical endpoints and endocrine relevant mechanistic biomarkers during the exposure to the test item on different life stages andgenerations of the zebrafish (Danio rerio).
No test substance-related effects on endocrine relevant endpoints (fertility, fecundity, sex ratio, vitellogenin content, gonad maturity)were observed up to the highest tested concentration of 1250 µg/L.
There was no adverse treatment related effect on time to hatch and larval survival.
Male body length was statistically significantly reduced in the highest tested concentration in comparison to the control group when using Williams test one-sided. However, this reduction was minimal and the variation of body length in all test groups was high and
overlapped. Nebvertheless, as male body weight was the lowest in test group 5 (statistically not significant) and higher concentrations than 1250 μg/L have not been tested, this minor effect will be considered as worst-case scenario, resulting in a LOEC for male body length at1250 μg/L.
In conclusion the overall NOEC identified in this test was 250 μg/L (nominal concentration), the LOEC was 1250 μg/L (nominal concentration) based on reduced male body length. Since no other test substance-related effects on endocrine relevant endpoints were observed in this study up to the highest tested concentration of 1250 μg/L,this study does not indicate any
evidence of endocrine activity for DHDPS.
Activated Sludge
The EC10 of the test substance to activated sludge was tested to be 200 mg/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.