Registration Dossier
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EC number: 215-213-6 | CAS number: 1313-96-8
Endpoint summary
Administrative data
Description of key information
Additional information
Acute aquatic toxicity data for diniobium pentaoxide (CAS 1313-96-8) is available for one trophic level, including one key study with aquatic algae (OECD 201). Chronic aquatic toxicity data for this substance is available for two trophic levels, i.e. freshwater algae and invertebrates, respectively. Furthermore, a long-term test with fish (OECD 210) is ongoing (ECHA decision number: CCH-D-2114517435-52-01/F). Reasons for the delay are summarized in the statements attached in IUCLID section 6.1.2 (status of fish early life stage toxicity test (OECD 210) with diniobium pentoxide, ECHA decision number: CCH-D-2114517435-52-01/F). The current assessment is based on the presently available data and will be adjusted as soon as further data become available.
In a freshwater algae study (OECD 201) an ErC10 (72 h) value of 4.03 mg/L (nominal) was obtained for diniobium pentaoxide (CAS 1313-96-8). However, the observed effects are linked to mechanical/physical effects of non-dissolved test material and not to the intrinsic toxic properties of the test item (for a detailed discussion see IUCLID section 6.1.5). No acute effects were observed up to the highest concentration tested, resulting in an ErC50 (72 h) of > 100 mg/L (nominal). Thus, diniobium pentaoxide is not acutely and chronically toxic to freshwater algae up to its solubility limit.
Diniobium pentaoxide did not cause chronic effects to Daphnia magna in a chronic toxicity test according to OECD 211 resulting in an 21 d NOEC value of ≥ 10 mg/L and (nominal).
No toxic effects to aquatic microorganisms were observed in an OECD 209 test (NOEC ≥ 1000 mg/L).
Thus the available acute and chronic ecotoxicity data show that, diniobium pentaoxide (CAS 1313-96-8) is not acutely and chronically toxic to freshwater organisms.
This conclusion will be re-evaluated, based on the results of the already ongoing long-term test with fish (OECD 210, CCH-D-2114517435-52-01/F).
All key studies were conducted according to appropriate guidelines and GLP conditions.
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