Registration Dossier
Registration Dossier
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EC number: 220-346-8 | CAS number: 2730-71-4
Guidance on Safe Use
Guidance on Safe Use
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Administrative data
First-aid measures
Description of first aid measures. In case of skin contact: Immediately take off all contaminated clothing.
Areas of the body that have - or are only even suspected of having - come into contact with the product must be rinsed immediately with plenty of running water and possibly with soap.
OBTAIN IMMEDIATE MEDICAL ATTENTION.
Wash thoroughly the body (shower or bath).
Remove contaminated clothing immediately and dispose off safely.
After contact with skin, wash immediately with soap and plenty of water.
In case of eyes contact: After contact with the eyes, rinse with water with the eyelids open for a sufficient length of time, then consult an
opthalmologist immediately.
Protect uninjured eye.
In case of Ingestion: Give nothing to eat or drink.
In case of Inhalation: If breathing is irregular or stopped, administer artificial respiration.
In case of inhalation, consult a doctor immediately and show him packing or label.
Most important symptoms and effects, both acute and delayed
Conjunctivitis
Indication of any immediate medical attention and special treatment needed
In case of accident or unwellness, seek medical advice immediately (show directions for use or safety data sheet if possible).
Treatment:
Treat symptomatically.
Areas of the body that have - or are only even suspected of having - come into contact with the product must be rinsed immediately with plenty of running water and possibly with soap.
OBTAIN IMMEDIATE MEDICAL ATTENTION.
Wash thoroughly the body (shower or bath).
Remove contaminated clothing immediately and dispose off safely.
After contact with skin, wash immediately with soap and plenty of water.
In case of eyes contact: After contact with the eyes, rinse with water with the eyelids open for a sufficient length of time, then consult an
opthalmologist immediately.
Protect uninjured eye.
In case of Ingestion: Give nothing to eat or drink.
In case of Inhalation: If breathing is irregular or stopped, administer artificial respiration.
In case of inhalation, consult a doctor immediately and show him packing or label.
Most important symptoms and effects, both acute and delayed
Conjunctivitis
Indication of any immediate medical attention and special treatment needed
In case of accident or unwellness, seek medical advice immediately (show directions for use or safety data sheet if possible).
Treatment:
Treat symptomatically.
Fire-fighting measures
Extinguishing media
Suitable extinguishing media: Water.
Carbon dioxide (CO2).
Extinguishing media which must not be used for safety reasons: None in particular.
Special hazards arising from the substance or mixture. Do not inhale explosion and combustion gases.
Burning produces heavy smoke.
Advice for firefighters
Use suitable breathing apparatus .
Collect contaminated fire extinguishing water separately. This must not be discharged into drains.
Move undamaged containers from immediate hazard area if it can be done safely.
Suitable extinguishing media: Water.
Carbon dioxide (CO2).
Extinguishing media which must not be used for safety reasons: None in particular.
Special hazards arising from the substance or mixture. Do not inhale explosion and combustion gases.
Burning produces heavy smoke.
Advice for firefighters
Use suitable breathing apparatus .
Collect contaminated fire extinguishing water separately. This must not be discharged into drains.
Move undamaged containers from immediate hazard area if it can be done safely.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Wear personal protection equipment.
Wear breathing apparatus if exposed to vapours/dusts/aerosols.
Provide adequate ventilation.
Use appropriate respiratory protection.
Environmental precautions
Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains.
Retain contaminated washing water and dispose it.
In case of gas escape or of entry into waterways, soil or drains, inform the responsible authorities.
Suitable material for taking up: absorbing material, organic, sand
Methods and material for containment and cleaning up Wash with plenty of water.
Wear personal protection equipment.
Wear breathing apparatus if exposed to vapours/dusts/aerosols.
Provide adequate ventilation.
Use appropriate respiratory protection.
Environmental precautions
Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains.
Retain contaminated washing water and dispose it.
In case of gas escape or of entry into waterways, soil or drains, inform the responsible authorities.
Suitable material for taking up: absorbing material, organic, sand
Methods and material for containment and cleaning up Wash with plenty of water.
Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes, inhalation of vapours and mists. Use localized ventilation system.
Exercise the greatest care when handling the product. Avoid the formation of dust clouds: as for all organic powders, explosion hazard may exist in presence of sparks, flames, static electricity etc., if dusts are released in the atmosphere.
Don't use empty container before they have been cleaned.
Before making transfer operations, assure that there aren't any incompatible material residuals in the containers.
Contamined clothing should be changed before entering eating areas.
Do not eat or drink while working.
Conditions for safe storage, including any incompatibilities
In well closed containers, protected from light-moisture-heat.
Keep away from unguarded flame, sparks, and heat sources. Avoid direct exposure to sunlight.
Avoid accumulating electrostatic charge.
Always keep in a well ventilated place.
Keep away from food, drink and feed.
Incompatible materials: None in particular.
Instructions as regards storage premises: Cool and adequately ventilated.
Specific end use(s): None in particular
Avoid contact with skin and eyes, inhalation of vapours and mists. Use localized ventilation system.
Exercise the greatest care when handling the product. Avoid the formation of dust clouds: as for all organic powders, explosion hazard may exist in presence of sparks, flames, static electricity etc., if dusts are released in the atmosphere.
Don't use empty container before they have been cleaned.
Before making transfer operations, assure that there aren't any incompatible material residuals in the containers.
Contamined clothing should be changed before entering eating areas.
Do not eat or drink while working.
Conditions for safe storage, including any incompatibilities
In well closed containers, protected from light-moisture-heat.
Keep away from unguarded flame, sparks, and heat sources. Avoid direct exposure to sunlight.
Avoid accumulating electrostatic charge.
Always keep in a well ventilated place.
Keep away from food, drink and feed.
Incompatible materials: None in particular.
Instructions as regards storage premises: Cool and adequately ventilated.
Specific end use(s): None in particular
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 1544
Shippingopen allclose all
Shipping Name: ALKALOIDS,SOLID, N.O.S. Or ALKALOID SALTS,SOLID, N.O.S. (thiocolchicine)
SpecialProvisionsopen allclose all
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
Shippingopen allclose all
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 1544
Shipping information
- Proper shipping name and description:
- ALKALOIDS,SOLID, N.O.S. Or ALKALOID SALTS,SOLID, N.O.S. (thiocolchicine)
- Chemical name:
- Thiocolchicine
- Labels:
- Labels: 6.1.
ALKALOIDS,SOLID, N.O.S. Or ALKALOID SALTS,SOLID, N.O.S. (thiocolchicine)
Special provisions / remarks
- Remarks:
- IATA- passenger Aircraft: Forbidden
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Control parameters
No occupational exposure limit available
DNEL Exposure Limit Values: N.A.
PNEC Exposure Limit Values: N.A.
Exposure controls
Eye protection: Eye glasses with side protection EN 166.
Protection for skin: Disposable overall DPI III CAT: Type 5 - ISO 13982-1. Type 6 – EN 13034
Protection for hands: Gloves for chemical uses DPI III CAT. EN 374-1. Depending on the application, the gloves must ensure permeation
times appropriate to EN 374-3.
Respiratory protection: APVR EN 149 – FFP3 or EN 143 – P3
Thermal Hazards: None
Environmental exposure controls: None
Appropriate engineering controls: None
No occupational exposure limit available
DNEL Exposure Limit Values: N.A.
PNEC Exposure Limit Values: N.A.
Exposure controls
Eye protection: Eye glasses with side protection EN 166.
Protection for skin: Disposable overall DPI III CAT: Type 5 - ISO 13982-1. Type 6 – EN 13034
Protection for hands: Gloves for chemical uses DPI III CAT. EN 374-1. Depending on the application, the gloves must ensure permeation
times appropriate to EN 374-3.
Respiratory protection: APVR EN 149 – FFP3 or EN 143 – P3
Thermal Hazards: None
Environmental exposure controls: None
Appropriate engineering controls: None
Stability and reactivity
Reactivity
Stable under normal conditions
Chemical stability: Stable under normal conditions
Possibility of hazardous reactions: None
Conditions to avoid: Stable under normal conditions.
Incompatible materials: None in particular.
Hazardous decomposition products: None.
Stable under normal conditions
Chemical stability: Stable under normal conditions
Possibility of hazardous reactions: None
Conditions to avoid: Stable under normal conditions.
Incompatible materials: None in particular.
Hazardous decomposition products: None.
Disposal considerations
Waste treatment methods
Recover, if possible. Send to authorised disposal plants or for incineration under controlled conditions. In so doing,
comply with the local and national regulations currently in force.
Recover, if possible. Send to authorised disposal plants or for incineration under controlled conditions. In so doing,
comply with the local and national regulations currently in force.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
