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Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail.

Data source

Reference
Reference Type:
other: thesis
Title:
Unnamed
Year:
2002

Materials and methods

Objective of study:
metabolism
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Butyl methacrylate
EC Number:
202-615-1
EC Name:
Butyl methacrylate
Cas Number:
97-88-1
IUPAC Name:
butyl methacrylate
Constituent 2
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
IUPAC Name:
2-ethylhexyl methacrylate
Details on test material:
Methacrylic acid from Ineos Acrylics (Lot 98/42; purity > 99%), methyl methacrylate from Ineos Acrylics (Lot 98/15; purity > 99%), ethyl methacrylat from Atofina (Lot 011666; purity: > 99%), i-butyl methacrylate from Ineos Acrylics (Lot 98/15; purity 99%), n-butyl methacrylate from Ineos Acrylics (Lot 98/15; purity 99%), hexyl methacrylate from Röhm GmbH (Lot 78070243; purity > 98%), 2-ethylhexyl methacrylate from Röhm GmbH (Lot 78080370; purity > 98%), octyl methacrylate from Röhm GmbH (Lot 22-902-13914-28; purity > 98%)

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
other: in vitro and intravenous in vivo

Results and discussion

Applicant's summary and conclusion