Registration Dossier
Registration Dossier
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EC number: 200-467-2 | CAS number: 60-29-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original publication not available. Data based on IUCLID data summary sheet.
Data source
Reference
- Reference Type:
- publication
- Title:
- Reduced synthesis of hepatic and plasma proteins in rats during diethyl ether anesthesia
- Author:
- Bessesen, A., Smith-Kielland, A., Gadeholt, G., Morland, J.
- Year:
- 1 983
- Bibliographic source:
- Acta Pharmacol. Toxicol., 1983, 54, 241-246
Materials and methods
- Type of study / information:
- Toxicodynamics study
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Effect of diethyl ether anesthesia on in vivo hepatic protein synthesis.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diethyl ether
- EC Number:
- 200-467-2
- EC Name:
- Diethyl ether
- Cas Number:
- 60-29-7
- Molecular formula:
- C4H10O
- IUPAC Name:
- diethyl ether
Constituent 1
Results and discussion
Any other information on results incl. tables
At anesthetic concentrations, the rate of liver protein synthesis was reduced by 20% compared to controls. The secretion of plasma proteins was reduced by 70 -80% compared to controls, or animals receiving pentobarbital.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
