Registration Dossier
Registration Dossier
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EC number: 204-424-9 | CAS number: 120-78-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- Principles of method if other than guideline:
- other: acute dermal toxicity study
- GLP compliance:
- no
- Test type:
- other: acute dermal toxicity study
Test material
- Reference substance name:
- Di(benzothiazol-2-yl) disulphide
- EC Number:
- 204-424-9
- EC Name:
- Di(benzothiazol-2-yl) disulphide
- Cas Number:
- 120-78-5
- Molecular formula:
- C14H8N2S4
- IUPAC Name:
- di(benzothiazol-2-yl) disulphide
- Details on test material:
- CP 1612
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 h
- Doses:
- 5010, 7940 mg/kg bw
- No. of animals per sex per dose:
- 1 to 2 animal per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: clinical signs: reduced appetite and activity one two days
Any other information on results incl. tables
Mortality: no death occurred during the study
5010 mg/kg: male 0/1, female -, combined 0/1
7940 mg/kg: male 0/1, female 0/1, combined 0/2
Clinical signs observed: reduced appetite and activity (one to two days)
Gross autopsy (survivors 14 days study termination): viscera appeared normal
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
