Diarsenic trioxide

Toxicity to other above-ground organisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to other above-ground organisms

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

Dietary toxicity study in dogs

GLP compliance:

not specified

Test organisms (species):

other: Canis familiaris

Details on test organisms:

female beagle dogs, 7 to 8 months old

Study type:

laboratory study

Total exposure duration:

183 d

Nominal and measured concentrations:

0.58, 1.15, 2.31 mg As/ kg diet

Key result

Duration:

183 d

Dose descriptor:

other: NOEL

Effect conc.:

1.04 other: mg/kg bw/d

Nominal / measured:

not specified

Conc. based on:

element

Remarks:

As

Basis for effect:

other: growth, feed consumption

Conclusions:

This study shows that dietary sodium arsenite causes a dose-dependent decrease of feed consumption and body weight in female dogs. A NOAEL of 1.04 mg As/kg bw/d was observed (based on a test concentration of 1.15 mg As/kg diet). Applying a conversion factorr of 40 (g bw/g diet per day), this NOAEL corresponds to a NOEC of 41.6 mg As/kg diet.

Description of key information

The lowest NOAEL for mammals (1.04 mg As/kg diet) was observed in a 183-days study with female beagle dogs exposed to exposed to arsenic via food (Neiger and Osweiler, 1989). Applying a conversion factor of 40 (g bw/g diet per day), this NOAEL corresponds to a NOEC of 41.6 mg As/kg diet.

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for mammals:

41.6 mg/kg food