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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study similar to guideline (limit test; non GLP, age of test animals not recorded)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
test substance evaluated at unique 10000 mg/kg dose level
Deviations:
yes
Remarks:
age of test animals not recorded
Principles of method if other than guideline:
BASF-Test
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Chromgelb 62 F
IUPAC Name:
Chromgelb 62 F
Details on test material:
- Name of test material (as cited in study report): chromgelb 62 F (chemical name: lead chromate, -sulfate)
- Physical state: crystal mixture
- Analytical purity: 85% PbCrO4
- Composition of test material, percentage of components: 85% PbCrO4 and 3%, also containing PbSO4, SbF3, Sb2O3 and SiO2 at unspecified percentages

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: SPF breed from WIGA, Sulzfeld
- Age at study initiation: no data
- Weight at study initiation: 205 g for males, 155 for females
- Fasting period before study: no data
- Diet: Altromin-R, Altrogge, Lage/L; ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
VEHICLE (aquous suspension with 0.5% CMC)
Dose (mg/kg bw) /10000
Concentrationof test substance in vehicle (%) /35
Applied volume (ml/kg) /28.57
Doses:
10000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily recording of signs and symptoms from the day of administration till the end of the observation period. Daily check (twice) for moribund and dead animals (once during the weekend).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Remarks on result:
other: no mortality at this unique dose level
Mortality:
no mortality observed
Clinical signs:
other: only feces coloration and urin (yellow) up to day 7 after treatment, nothing abnormal afterwards
Gross pathology:
nothing abnormal detected

Any other information on results incl. tables

Table 1: Body weight

Mean body weight at)

day after application

0

4

7

14

Males

205

227

246

264

Females

155

170

180

180

Applicant's summary and conclusion