Registration Dossier
Registration Dossier
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EC number: 202-532-0 | CAS number: 96-76-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in 1959. It is not a guideline study and is non-GLP.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test material prepared as a suspension in peanut oil was placed in contact with intact abdominal skin of rabbits for 6 hours
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-di-tert-butylphenol
- EC Number:
- 204-884-0
- EC Name:
- 2,6-di-tert-butylphenol
- Cas Number:
- 128-39-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- 2,6-di-tert-butylphenol
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Rats were exposed for 7h to varying amounts of test substance (AN-33) 3.2 to 10 ml per kg.
- Duration of exposure:
- 7 hours
- Doses:
- 3.2 to 10 ml per kg
- No. of animals per sex per dose:
- No data
- Control animals:
- no
- Details on study design:
- No details
Results and discussion
- Preliminary study:
- The rats had no local injuries and showed no signs of systemic illness following dermal exposure.
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 10 mL/kg bw
- Based on:
- other: technical containing 70-80% 2,6-di-tert-butylphenol
- Mortality:
- None
- Clinical signs:
- other: No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Not classified for dermal toxicity.
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