Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-400-5 | CAS number: 106-46-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,4-dichlorobenzene
- EC Number:
- 203-400-5
- EC Name:
- 1,4-dichlorobenzene
- Cas Number:
- 106-46-7
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,4-dichlorobenzene
- Test material form:
- other: solid
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
content: 99.9 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3,4- 3,5 kg.
- Housing: individually
- Diet ad libitum
- Water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 50
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Vehicle:
- not specified
- Controls:
- other: the untreated second eye served as control
- Amount / concentration applied:
- 100 µl (bulk volume = ca 90 mg test substance)
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Ca 90 mg ofundissolved test substance was applied into the conjunctival sac of one eye (ther other served as control) of each of 3 rabbits; lids were pressed together for one second. 24 hours later the treated eyes were rinsed with saline solution and observed for further 7 days. Eye reactions were evauated according to Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: up to 48h
- Score:
- ca. 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: a reddening an swelling was observed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 7d
- Score:
- ca. 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: not irritant or corrosive
- Irritant / corrosive response data:
- No irritating effects were observed
Any other information on results incl. tables
no irritant or corrosive effect in rabbit eye.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Eye irritation was tested in rabbits using the OECD TG 405. Ca 90 mg of undissolved test substance was applied into the conjunctival sac of one eye (the other served as control) of each of 3 rabbits and lids were pressed together for one second. 24 hours later the treated eyes were rinsed with saline solution and observed for further 7 days. Eye reactions were evauated according to Draize.
P-dichlorobenzene had no irritating or corrosive effect in adult rabbit eyes.Therefore no local risk potential for eyes of rabbits exists
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
