Registration Dossier
Registration Dossier
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EC number: 203-400-5 | CAS number: 106-46-7
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: observations in humans
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: observation in humans
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Paradichlorobenzene- Determination on Animals and Human Subjects
- Author:
- Hollingsworth R.L.
- Year:
- 1 956
- Bibliographic source:
- Arch.Industr.Health, 14, 1956
Materials and methods
- Type of study / information:
- observation in humans
- Endpoint addressed:
- eye irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- observation in humans: 58 workers, 8 hours /day 5 days/week, for 8 months up to 25 years
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-dichlorobenzene
- EC Number:
- 203-400-5
- EC Name:
- 1,4-dichlorobenzene
- Cas Number:
- 106-46-7
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,4-dichlorobenzene
- Test material form:
- other: solid
- Details on test material:
- no further data
Constituent 1
Method
- Ethical approval:
- not applicable
- Details on study design:
- observations in humans
Results and discussion
- Results:
- Industrial workers which were indefinitely exposed to 10 -550 ppm (92 -3366 mg/m³) p-DCB did not announce any disturbances at 15 -85 ppm (average: 45 ppm; 92 -520 mg/m³, average 275 mg/m³). At 50 -170 ppm (average 105 ppm; 306 -1040 mg/m³; average 643 mg/m³) the workers specified irritations of eyes and nose. These effects were more severe at 160 ppm (979 mg/m³) p-DCB. At 15 -30 ppm a slight smell was noticed, which was strong at 30 -60 ppm. At higher concentrations the smell was not tolerable.
The NOAEC therefore is <50 ppm.
Applicant's summary and conclusion
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