Registration Dossier
Registration Dossier
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EC number: 247-781-6 | CAS number: 26544-38-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance has low water solubility, moderate octanol/water partition coefficient, and low vapour pressure. It may be absorbed from the gastrointestinal tract, but has low absorption via the skin and respiratory tract. It may be distributed to organs, but is quickly hydrolysed and eliminated in the urine. Metabolism/hydrolysis is to the dioic acid.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 10
Additional information
The ASA category compounds are viscous liquid or semisolid substances with moderate octanol/water partition coefficients and sparingly soluble to insoluble water solubilities. These characteristics indicate that alkenyl succinic anhydrides are slightly lipophilic, and thus, capable of passive diffusion across biological membranes. ASA category members are also hydrolytically unstable and the resulting species are known to react with proteins. Thus it can be predicted that upon oral exposure these chemical substances would be absorbed by the gastrointestinal tract with an absorption rate >50%. The structural and physical properties of each compound including comparatively high molecular weight, the presence of long-chain tetrapropenyl moieties and sparingly water solubility, is expected to reduce the rate and extent of dermal absorption, thus dermal absorption rate is likely <10%. The alkenyl succinic anhydrides have relatively high boiling points, low vapor pressure, and are viscous liquids and thus have a low propensity to form vapors or aerosols, therefore exposure via inhalation is not likely and the inhalation absorption rate is also likely < 10%. Following absorption distribution can occur to highly perfused organs such as the kidney. The lack of target organ toxicity other than the kidney is an indication that members of the ASA category are not widely distributed in the body. Alkenyl succinic anhydrides are hydrolyzed to dicarboxylic acids and excreted in urine as the corresponding acids. While ASA category members are sparingly water soluble, they hydrolytically degrade to dicarboxylic acids and based on excretion data for other acid anhydrides are eliminated with a half time that would indicate little bioaccumulation potential.
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