Registration Dossier
Registration Dossier
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EC number: 201-236-9 | CAS number: 79-94-7
Endpoint summary
Administrative data
Description of key information
Additional information
Several studies have investigated TBBPA’s potential for absorption and elimination in environmentally relevant species, e.g. fish, oysters, birds, earthworms. The results are consistent with similar studies in humans and rats (see section 5.1 of the CSR) demonstrating that TBBPA is rapidly metabolized and eliminated and has little to no potential for bioaccumulation.
After exposure to TBBPA in water, fish rapidly reached steady-state tissue concentrations with measured BCFs of ca. 150. Fish also rapidly eliminated TBBPA once removed to fresh water with 50% elimination of the 14C-residues present in the tissue of fathead minnows on the last day of exposure occurring during the first 24 hours of depuration. After oral exposure of quail, TBBPA was rapidly eliminated via bile and excreted in faeces, and transfer to egg yolks was low. After egg yolk injection, TBBPA’s transfer to the growing embryo was low, and that amount transferred was readily excreted by the embryo. Thus, the risk for bioaccumulation or embryonic exposure following dietary intake in laying birds is expected to be low. TBBPA did not bioaccumulate in earthworms after prolonged exposure. Based on these studies, TBBPA has little potential to bioconcentrate or bioaccumulate. This is likely related to the organisms’ ability to metabolize TBBPA to readily eliminated forms.
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