Registration Dossier
Registration Dossier
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EC number: 213-879-2 | CAS number: 1047-16-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ETAD Analytical Expert Group
- Version / remarks:
- method for substances with very low solubility in both, water and n-octanol
- Principles of method if other than guideline:
- Determination of solubility in water saturated n-octanol and in n-octanol saturated water and calculation of log Pow
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- EC Number:
- 213-879-2
- EC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 1047-16-1
- Molecular formula:
- C20H12N2O2
- IUPAC Name:
- 5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione
- Test material form:
- solid: nanoform
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 159
- Temp.:
- 24 °C
- pH:
- ca. 7
- Type:
- log Pow
- Partition coefficient:
- 2.2
- Temp.:
- 24 °C
- pH:
- ca. 7
- Details on results:
- Pow and log Pow were calculated from the solubilities in n-octanol saturated water and water saturated n-octanol (see below)
Any other information on results incl. tables
The following solubilities were obtained:
- Solubility in n-octanol saturated water: mean 18.8 µg/L (sigma = 2.3, individual values: 17.2, 17.8 and 21.4 µg/L)
- Solubility in water saturated n-octanol: mean 2980 µg/L (sigma = 0.05, individual values: 2930, 2990 and 3030 µg/L)
These solubilities are used to calculate Pow with the following equation:
Pow = solubility in water saturated n-octanol / n-octanol saturated water
Pow = 2980 µg/L / 18.8 µg/L
Pow = 159
log Pow = 2.2
This value is based on measurements taken at 24 -25°C (24°C entered above)
Applicant's summary and conclusion
- Conclusions:
- The test substance has a log Pow of 2.2.
- Executive summary:
- The log Pow of the test substance C.I. Pigment Violet 19 was calculated from the solubilities in n-octanol saturated water and in water saturated n-octanol. The log Pow at 24 -25°C was 2.2.
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