Registration Dossier
Registration Dossier
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EC number: 202-716-0 | CAS number: 98-95-3
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: range finding study
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not yet available
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report (Draft), NITROBENZENE CAS No: 98-95-3
- Author:
- European Chemicals Bureau
- Year:
- 2 007
Materials and methods
- Principles of method if other than guideline:
- no data given in European Union Risk Assessment Report (Draft) (2007)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- other: skin painting
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
200 to 3200 mg/kg bw/d
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
All rats at the 1600 and 3200 mg/kg bw/d doses died or were sacrificed moribund prior to the end of treatment. Treated animals were inactive, ataxic, prostrate and dyspnoeic. Histologically, rats showed changes in the brain, liver, spleen and testes. Reticulocyte counts and methaemoglobin levels were increased (all dosage groups); haemoglobin and red blood cells were decreased. No quantitative details on blood parameters included in the report.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
