Registration Dossier
Registration Dossier
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EC number: 202-716-0 | CAS number: 98-95-3
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, however, limited documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Selective degeneration in the rat olfactory bulb following exposure to different odours
- Author:
- Pinching AJ, Doving KB
- Year:
- 1 974
- Bibliographic source:
- Brain Research 82: 195-204
Materials and methods
- Principles of method if other than guideline:
- Animals were exposed to constant nitrobenzene vapour. The animals were sacrificed at about 1, 2 and 3 months of age. As to control, animals exposed to filtered fresh air only.
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): Nitrobenzene
- Molecular formula (if other than submission substance): C6H5NO2
- Molecular weight (if other than submission substance): 123
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 2 weks
- Weight at study initiation: 28 - 39 g
- Fasting period before study: no dat
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- other: room air filtered through filters of charcoal and molecular sieves
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 or 10 weeks
Sacrifice after 5 and 10 weeks, respectively - Frequency of treatment:
- continuously constant
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5.4E-111M
Basis:
other: Difference of the weight between before and after the experiment.
- No. of animals per sex per dose:
- 4 totally, no data about the sexuality of animals tested
- Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
Microscopic examination of the olfactory bulb revealed a degeneration of the mitral cell layer, representing the principal relay neurones, with the most densely degeneration in the ventral region.
Applicant's summary and conclusion
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