Registration Dossier
Registration Dossier
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EC number: 203-539-1 | CAS number: 107-98-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Three studies - conducted in three different species - are available to assess acute toxicity of propylene glycol methyl ether to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6 812 mg/L
Additional information
A non-GLP-study (according to DIN 38412) with Leuciscus idus was carried out under static conditions at 20-22°C. Based on nominal concentrations of propylene glycol methyl ether, the 96-hour LC50 was calculated to be 6812 mg/l. The No Observed Effect Concentration (NOEC) was determined to be 4640 mg/l. For a GLP-study according to an ASTM method the 96-hour LC50 based on nominal concentrations of propylene glycol methyl ether was determined to be 20800 mg/l. According to the Directive 92/CEE, method C1 “acute toxicity of fish”, a water temperature between 20 and 24°C is recommended for Pimephales promelas. Therefore, this test can be considered as valid but with restrictions. A non-GLP study similar to OECD guideline 203 studied the acute toxicity of propylene glycol methyl ether to Oncorhynchus mykiss. The exposure concentration was 1000 mg/l. Based on this nominal concentration, the 96-hour LC50 was determined to be superior to 1000 mg/l since no mortality was observed throughout the test.
The 96-hour LC50 (6812 mg/l) will be taken into account for the risk assessment.
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