Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-727-4 | CAS number: 12626-81-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The mutagenicity of lead chloride was examined in Chinese hamster ovary AS52 cells at concentrations from 0.1 - 1.0 uM.
- GLP compliance:
- not specified
- Type of assay:
- other: mammalian cell gene mutation assay
Test material
- Reference substance name:
- Lead chloride
- IUPAC Name:
- Lead chloride
- Test material form:
- solid
- Details on test material:
- CAS number not specified
Constituent 1
- Specific details on test material used for the study:
- CAS number not specified
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- not specified
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- other: Test system: all strains/cell types tested
Any other information on results incl. tables
Lead chloride had little effect on cell viability up to concentrations of 0.5 uM. Lead chloride induced a dose-dependent increase in the isolation of mutants resistant to 6-thioguanine (TG) compared to controls.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: positive
- Executive summary:
The mutagenicity of lead chloride was examined in Chinese hamster ovary AS52 cells at concentrations from 0.1 - 1.0 uM. Lead chloride had little effect on cell viability up to concentrations of 0.5 uM. Lead chloride induced a dose-dependent increase in the isolation of mutants resistant to 6-thioguanine (TG) compared to controls.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
