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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

No particular data available. Isopropylamine is expected to be readily eliminated from the organism either metabolised by oxidative desamination, thus resulting in acetone, or excreted from the body in unchanged form.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Isopropylamine is assumed to be readily bioavailable by all potential routes of exposure. Exposure may mainly occur by inhalation

and by skin contact. Dermal uptake may differ, depending on the application form (direct application of liquid isopropylamine, vapour exposure)

It can be concluded that ingested isopropylamine is no proper substrate of MAO, but partly may undergo methyl- or N-oxidation.

But a substantial part is expected to be excreted unchanged into the urine. If oxidative deamination occurs, acetone will be formed.

This is usually exhaled as well as excreted into the urine. Small amounts of acetone are normally formed in the intermediary metabolism through spontaneous or enzymatic decarboxylation of acetoacetate.


Overall, isopropylamine will not accumulate and is not expected to form harmful intermediates (Cavender et al. 2000).

Thredgold et al. (2018) did not observe a relevant uptake via skin after in vitro exposure of human skin to isopropylamine vapour (3000 ppm) for 20 or 30 min. Skin penetration was < 1µg at the end of the exposure period and skin absorption < 12 µg.