Registration Dossier
Registration Dossier
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EC number: 202-476-7 | CAS number: 96-09-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication/study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data - List V
- Author:
- Smyth H F et al.
- Year:
- 1 954
- Bibliographic source:
- Archives of Industrial Hygiene and Occupational Medicine (1954), 10, 61-8
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- Deviations:
- yes
- GLP compliance:
- no
- Remarks:
- Study performed before implementation of GLP
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- (epoxyethyl)benzene
- EC Number:
- 202-476-7
- EC Name:
- (epoxyethyl)benzene
- Cas Number:
- 96-09-3
- Molecular formula:
- C8H8O
- IUPAC Name:
- 2-phenyloxirane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Remarks on duration:
- see "Concentrations"
- Concentrations:
- 500 ppm for 4 h
concentrated vapour (defined as nearly saturated) for 1 h - No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 500 ppm
- Exp. duration:
- 4 h
- Mortality:
- 2/6 at 500 ppm for 4 h
none at 1 h concentrated vapour - Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Executive summary:
In an acute inhalation toxicity study, groups of 6 young adult male Carworth-Wistar rats were exposed by inhalation route to of styrene oxide for 4 hours at concentrations of 500 ppm mg/L. Animals then were observed for 14 days.
LC50Males > 0.5 ml/L for 4 h
Styrene Oxide is classified as being of LOW Toxicity based on males.
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