Registration Dossier
Registration Dossier
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EC number: 201-070-7 | CAS number: 77-93-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1958
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study not under GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology of the Citric Acid Esters: Tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate
- Author:
- Finklestein M and Gold H
- Year:
- 1 959
- Bibliographic source:
- Toxicol. Applied Pharmacol. 1(3):283-292
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- Information on methods was not provided in this reliable textbook/review article. Practical handling experience has not resulted in the questioning of the accuracy of this data.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triethyl citrate
- EC Number:
- 201-070-7
- EC Name:
- Triethyl citrate
- Cas Number:
- 77-93-0
- Molecular formula:
- C12H20O7
- IUPAC Name:
- triethyl citrate
- Test material form:
- not specified
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- TEC was administered via oral gavage at 1 - 9.5ml/kg bw.
- Doses:
- 1 - 9.5 ml/kg bw
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data
- Clinical signs:
- other: Nausea, vomiting, ataxia, weakness, muscle twitching, tremors, reflex hypersensitivity, lowering of body temperature, gasping and shallow respiration, prostration, convulsions, respiratory failure and death.
- Gross pathology:
- No gross abnormalities of the thoracic or abdominal organs that could be related to the toxic effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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