Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-247-9 | CAS number: 80-07-9
Neurotoxicity
Administrative data
Description of key information
No neurotoxic effects were observed in the 14 week studies in rat and mouse (NIH, 2001).
Key value for chemical safety assessment
Additional information
Rats and mice exposed to DCDPS were subject functional observation screening battery of tests (NIH, 2001). This battery included tests to assess several aspects of neurologic function including autonomic, convulsive, excitability, neuromuscular, sensorimotor, and general motor activity domains. No significant signs for neurotoxicity were observable in the 14 week studies of NIH (2001) up to dose levels of 480 mg/kg bw/day in mouse and 200 mg/kg bw/day in rat.
Justification for classification or non-classification
The available observations give no evidence for significant neurotoxic effects. No effect level is derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
