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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

EC50, activated sludge: > 5000 mg/L
NOEC, activated sludge: > 5000 mg/L

Key value for chemical safety assessment

EC50 for microorganisms:
5 000 mg/L
EC10 or NOEC for microorganisms:
5 000 mg/L

Additional information

Under 13.2 attached is the justification for read across to existing data from triethylene glycol dimethyl ether (Triglyme, CAS 112-49-2) as an appropriate source molecule. It is hypothesized that triglyme can be used as analogue to tetraglyme, because they share the same toxic mode of action so that read across among each other can be used to assess the acute aquatic toxicity of the individual members.The appropriateness of the chosen source molecule is based on structural and functional similarities, comparable physicochemical properties, common metabolic pathway(s), and a similar mode of action indicating a comparable ecotoxicological profile for tetraglyme as the target substance and triglyme as the source substance.

The read across key-study from Triglyme is available in activated sludge for toxicity to microorganisms. The NOEC (EC10) after 3 h determined was > 5000 mg/L. All results are shown in the "short description of key information" field.