Registration Dossier
Registration Dossier
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EC number: 201-126-0 | CAS number: 78-59-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Contribution a l'etude analytique toxicologique et biochimique de l'isophorone.
- Author:
- Dutertre-Catella H
- Year:
- 1 976
- Bibliographic source:
- Thesis, Universite Rene Descartes, Paris.
Materials and methods
- Principles of method if other than guideline:
- Method: other: see Reference
- GLP compliance:
- not specified
Test material
- Reference substance name:
- no data available
- IUPAC Name:
- no data available
- Details on test material:
- IUCLID4 Test substance: other TS: Elf Atochem S.A.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 8 weeks
- Frequency of treatment:
- daily on shaved skin
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 ml; 0.2 ml
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: yes, duration not reported
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:
- Mortality and time to death:
females: no mortalities
males: 1/5 in all groups including control
- Body weight gain:
males: similar in treated and untreated animals
females: reduced by approximately 8 % in treated animals as compared to controls
- Gross pathology: formation of erythema and crust on skin after 5-6 weeks of treatment was completely reversed after end of treatment
- Histopathology: confirmation of complete disappearance of erythema and crust; no differences between exposed and untreated animals were observed in any organ
Applicant's summary and conclusion
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