Registration Dossier
Registration Dossier
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EC number: 214-946-9 | CAS number: 1222-05-5
Endpoint summary
Administrative data
Description of key information
The aquatic BCF for HHCB 1584 l/kg is based on a WoE and the key value is derived from an aquatic OECD TG 305 test.
The BCF for HHCB-lactone is derived from the HHCB-dietary BMF, in which also the depuration of HHCB-lactone was measured, and this results in a BCF of 1293 l/kg
HHCB-hydroxylated-carboxylic acid has a negligible BCF based on the log Kow of 0.6 based on the dissociated acid at environmental pH as calculated with SPARC.
The terrestrial BCF for earthworms for HHCB is calculated with EUSES and results in a BCF of 2400 l/kg, which is considered conservative because it does not consider metabolisation of HHCB.
Air-breathing organisms accumulation: Though the bioaccumulation criteria in air breathing organisms are fulfilled for HHCB: Koa > 5 and Kow > 2, the criteria for absence of metabolisation and main excretion pathway via lungs are not fulfilled. Also the indicative final DT50 criteria are not fulfilled. After oral dosing of 2 and 20 mg/kg bw de half-lives in plasma and milk are < 24 hours In adipose tissue this DT50 is ca 50 hours. This latter DT50 can be compared to the indicative cut off mentioned in ECHA’s PBT guidance (R.11, page 84) of 2.5 days for shrews (a mouse species) and shows that there is no concern for air-breathing organisms (see also toxic-kinetic section).
Additional information
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