Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

not sensitising, OECD 429: S.I. of  1.1, 0.7 and 0.5 at 25%, 50% and 100% v/v

not sensitising based on human data

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Based on reliable animal studies and human data, glycerol is not a dermal sensitizer

There was a negative result obtained in a local lymph node assay (LLNA) with glycerol. Compared to dimethylformamide (stimulation index 1) used as vehicle, testing with 25%, 50% or 100% glycerol resulted in a stimulation index of 1.1; 0.7 and 0.5, respectively (Ryan et al. 2000).

In the available evaluation performed by an official body (OECD 2002) one additional animal study (Hine 1953) with a clear negative result and some human experience was evaluated and summarised.

Conclusion: Based on the available information, there is no human or animal data that indicates glycerol to be a skin sensitiser. Considering the extensive, widespread dermal exposure to glycerol in preparations repeatedly applied to the skin, the absence of case reports of humans showing skin reactions is consistent with glycerol having a very low skin sensitisation potential.


There was no new relevant information identified up to and including 2021 (most recent literature research).


Glycerol, CAS Number 56-81-5, OECD SIDS Initial Assessment Report For SIAM 14 Paris, France, 26-28 March 2002

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:
Migrated from Short description of key information:
Although no study has been conducted to determine whether glycerol is a respiratory sensitizer, there is no indication from a 13-week inhalation study that respiratory sensitization is a concern.

Justification for classification or non-classification

There is no justification for classification based on data from available studies.