Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

As the substance is a salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the read across substance melamine CAS 108 -78 -1 is justified. All effect values are minimum values as the molar ratio anion: cation equals 1.74.

 

Short-term toxicity to fish

No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. According to Pagga, 1979 (BASF SE) a 48h-LC50 > 500 mg/L was determined on Leuciscus idus. The substance is acutely not harmful to fish.

 

Long-term toxicity to fish

No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. The studies of Adema, 1982 (DSM) and Goodrich, 1984 (American Cyanamid) with comparable reliability and adequacy were used in a weight of evidence approach. The NOEC for the egg/larvae stage was determined to be >1000 mg/L. Both results indicate a low subchronic toxicity to developmental fish.

 

Short-term toxicity to aquatic invertebrates

No data with the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied. Based on the reported studies, which are consistent, an EC50 of 200 mg/L was determined in a study (Frazier, 1988 (American Cyanamid Co.)) performed with Daphnia magna. The substance is acutely not harmful to freshwater invertebrates.

 

Long-term toxicity to aquatic invertebrates

The chronic toxicity to aquatic invertebrates was assessed in a study (BASF SE, 2014) conducted with the target substance according to OECD 211 (2012). Daphnia magna was exposed to the test substance for 22 days. The NOEC based on reproduction was determined to be > 10 mg/L. The chronic toxicity and the reproduction toxicity of melamine to Daphnia magna is low.

 

Toxicity to algae and cyanobacteria

No data with the test substance were available. A weight of evidence approach with the read across substance melamine (CAS 108-78-1) is applied. Based on the reported studies, which are consistent, an EC50 of 325 mg/L and a NOEC of 98 mg/L were determined in a study performed with Pseudokirchneriella subcapitata (Drodowski, 1988 (American Cyanamid)).

 

Toxicity to microorganims

No data with the test substance were available. A weight of evidence approach with the read across substance melamine (CAS 108-78-1) is applied.

The study of Hockenbury 1977 is the relatively best reported one and was therefore selected as the lead study in the weight of evidence approach. After 2 hours the EC0 was determined to be > 100 mg/L. The toxicity of melamine to 3 different microorganisms is low.