Registration Dossier
Registration Dossier
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EC number: 201-280-9 | CAS number: 80-46-6
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study was not performed as per guidelines and does not provide traditional endpoints. However, study results are important in assessing overall risk with respect to oestrongenic effects.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of ethinylestradiol, diethylstilbestrol, 4- t-pentylphenol, 17β-estradiol, methyltestosterone and flutamide on sex reversal in S-rR strain medaka (Oryzias latipes).
- Author:
- Hagino S, Kagoshima M & Ashida S,
- Year:
- 2 001
- Bibliographic source:
- Environ Sci, 8, 75–87.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-tert-pentylphenol
- IUPAC Name:
- 4-tert-pentylphenol
- Details on test material:
- Purity: 99.7%
Constituent 1
Results and discussion
Any other information on results incl. tables
The 28 -day sex-reversal NOECs for male secondary sexual characteristics are:
Dorsal fin length = 0.01 mg/L
Anal fin length = 0.01 mg/L
Papillary processes on anal fin = 0.001 mg/L
Differentiation of male testes into ovaries = 0.001 mg/L
No statistical support was provided for results.
Applicant's summary and conclusion
- Conclusions:
- a study was conducted exposing newly hatched fish, Oryzias latipes, to the test substance for 28 days. Sex reversal effects for male secondary sexual characteristics were measured.
- Executive summary:
Hagino et al.( 2001) conducted a study (Klimisch 3) where newly hatched medaka (Oryzias latipes) were exposed to p-tert-amylphenol in a flow-through system for 28 days. Male secondary sex characteristics were evaluated and the NOEC determined for the following:
Dorsal fin length = 0.01 mg/L
Anal fin length = 0.01 mg/L
Papillary processes on anal fin = 0.001 mg/L
Differentiation of male testes into ovaries = 0.001 mg/L.
Although the study was not conducted according to acceptable methods, it is presented here for support for oestrogenic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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